{"id":1468,"date":"2023-03-03T20:11:07","date_gmt":"2023-03-03T20:11:07","guid":{"rendered":"https:\/\/www.lunit.io\/publication\/mammographic-density-reduction-is-associated-to-the-prognosis-in-asian-breast-cancer-patients-receiving-hormone-therapy\/"},"modified":"2025-11-02T13:08:59","modified_gmt":"2025-11-02T13:08:59","slug":"mammographic-density-reduction-is-associated-to-the-prognosis-in-asian-breast-cancer-patients-receiving-hormone-therapy","status":"publish","type":"publication","link":"https:\/\/www.lunit.io\/en\/publication\/mammographic-density-reduction-is-associated-to-the-prognosis-in-asian-breast-cancer-patients-receiving-hormone-therapy\/","title":{"rendered":"Mammographic density reduction is associated to the prognosis in Asian breast cancer patients receiving hormone therapy"},"content":{"rendered":"<h3>Mammographic Density Reduction is Associated to the Prognosis in Asian Breast Cancer Patients Receiving Hormone Therapy<\/h3>\n<p>W. C. Shia; L. S. Lin; H. K. Wu; C. J. Chen; D. R. Chen<\/p>\n<p><strong>Cancer Control, 2023<\/strong><\/p>\n<p><strong>Abstract<\/strong><br \/>\n<strong>Introduction<\/strong><br \/>\nUsing mammographic density as a significant biomarker for predicting prognosis in adjuvant hormone therapy patients is controversial due to the conflicting results of recent studies. This study aimed to evaluate hormone therapy-induced mammographic density reduction and its association with prognosis in Taiwanese patients.<\/p>\n<p><strong>Methods<\/strong><br \/>\nIn this retrospective study, 1941 patients with breast cancer were screened, and 399 patients with estrogen receptor-positive breast cancer who received adjuvant hormone therapy were enrolled. The mammographic density was measured using a fully automatic estimation procedure based on full-field digital mammography. The prognosis included relapse and metastasis during treatment follow-up. The Kaplan-Meier method and Cox proportional hazards model were used for disease-free survival analysis.<\/p>\n<p><strong>Results<\/strong><br \/>\nA mammographic density reduction rate &gt;20.8%, measured preoperatively and after receiving hormone therapy from 12-18 months, was a significant threshold for predicting prognosis in patients with breast cancer. The disease-free survival rate was significantly higher in patients whose mammographic density reduction rate was &gt;20.8% (P = .048).<\/p>\n<p><strong>Conclusion<\/strong><br \/>\nThis study\u2019s findings could help estimate the prognosis for patients with breast cancer and may improve the quality of adjuvant hormone therapy after enlarging the study cohort in the future.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748231160991\"><strong>Read the full paper<\/strong><\/a><\/p>\n","protected":false},"featured_media":0,"template":"","publication-oncology":[],"publication-region":[87],"publication-type":[],"radiology":[127,121],"class_list":["post-1468","publication","type-publication","status-publish","hentry","publication-region-asia","radiology-breast-cancer-prevention-volpara","radiology-volpara"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mammographic density reduction is associated to the prognosis in Asian breast cancer patients receiving hormone therapy - Lunit<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lunit.io\/en\/publication\/mammographic-density-reduction-is-associated-to-the-prognosis-in-asian-breast-cancer-patients-receiving-hormone-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mammographic density reduction is associated to the prognosis in Asian breast cancer patients receiving hormone therapy - Lunit\" \/>\n<meta property=\"og:description\" content=\"Mammographic Density Reduction is Associated to the Prognosis in Asian Breast Cancer Patients Receiving Hormone Therapy W. C. Shia; L. S. Lin; H. K. Wu; C. J. Chen; D. R. 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