{"id":1492,"date":"2025-03-17T20:11:14","date_gmt":"2025-03-17T20:11:14","guid":{"rendered":"https:\/\/www.lunit.io\/publication\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\/"},"modified":"2026-09-23T10:53:34","modified_gmt":"2026-09-23T01:53:34","slug":"subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection","status":"publish","type":"publication","link":"https:\/\/www.lunit.io\/en\/publication\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\/","title":{"rendered":"Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection"},"content":{"rendered":"<h1><strong>Abstract<\/strong><\/h1>\n<p>AI models show potential to improve breast cancer screening, however detailed subgroup evaluations to uncover the strengths and weaknesses of models are lacking. This study presents a granular evaluation of a commercial AI model for cancer detection on digital breast tomosynthesis (DBT) on a retrospective cohort of 167,860 screening exams in female patients. Performance in distinguishing screen detected cancers (1,368 exams) from negative exams (166,387 exams) is stratified across demographic, imaging, and pathologic subgroups to identify disparities. The overall AUROC is 0.91 and sensitivity is 0.73 with robust performance across demographics. In-situ cancers (AUROC: 0.85, sensitivity: 0.55), calcifications (AUROC: 0.80, sensitivity: 0.66), and dense breast tissue (AUROC: 0.88, sensitivity: 0.63) are associated with lower performance, while masses (AUROC: 0.93, sensitivity: 0.85) and architectural distortions (AUROC: 0.90, sensitivity: 0.83) are associated with higher performance. These results highlight the need for detailed evaluations and vigilance in adopting new clinical tools.<\/p>\n<p style=\"text-align: left;\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-026-70637-3\"><strong>Read the full paper<\/strong><\/a><\/p>\n","protected":false},"featured_media":0,"template":"","publication-oncology":[],"publication-region":[91],"publication-type":[],"radiology":[103,97,96],"class_list":["post-1492","publication","type-publication","status-publish","hentry","publication-region-north-america","radiology-ai-generalization-real-world-evidence","radiology-breast","radiology-lunit-insight"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection - Lunit<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lunit.io\/en\/publication\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection - Lunit\" \/>\n<meta property=\"og:description\" content=\"Abstract AI models show potential to improve breast cancer screening, however detailed subgroup evaluations to uncover the strengths and weaknesses of models are lacking. This study presents a granular evaluation of a commercial AI model for cancer detection on digital breast tomosynthesis (DBT) on a retrospective cohort of 167,860 screening exams in female patients. Performance [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.lunit.io\/en\/publication\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\/\" \/>\n<meta property=\"og:site_name\" content=\"Lunit\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-23T01:53:34+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@lunit_ai\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/publication\\\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\\\/\",\"url\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/publication\\\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\\\/\",\"name\":\"Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection - Lunit\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/#website\"},\"datePublished\":\"2025-03-17T20:11:14+00:00\",\"dateModified\":\"2026-09-23T01:53:34+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/publication\\\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.lunit.io\\\/en\\\/publication\\\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/publication\\\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/\",\"name\":\"Lunit\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/#organization\",\"name\":\"Lunit\",\"url\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/Logo-black.svg\",\"contentUrl\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/Logo-black.svg\",\"width\":189,\"height\":52,\"caption\":\"Lunit\"},\"image\":{\"@id\":\"https:\\\/\\\/www.lunit.io\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/lunit_ai\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/lunit-inc\",\"https:\\\/\\\/x.com\\\/lunitoncology\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection - Lunit","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.lunit.io\/en\/publication\/subgroup-performance-of-a-commercial-digital-breast-tomosynthesis-model-for-breast-cancer-detection\/","og_locale":"en_US","og_type":"article","og_title":"Subgroup Performance of a Commercial Digital Breast Tomosynthesis Model for Breast Cancer Detection - Lunit","og_description":"Abstract AI models show potential to improve breast cancer screening, however detailed subgroup evaluations to uncover the strengths and weaknesses of models are lacking. 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